Thesis etd-11052022-130218 |
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Thesis type
Tesi di specializzazione (4 anni)
Author
RUGGERI, SONIA
URN
etd-11052022-130218
Thesis title
Infezione da HPV e microbiota rettale: studio preliminare di correlazione.
Department
RICERCA TRASLAZIONALE E DELLE NUOVE TECNOLOGIE IN MEDICINA E CHIRURGIA
Course of study
MICROBIOLOGIA E VIROLOGIA
Supervisors
relatore Prof.ssa Ghelardi, Emilia
correlatore Dott.ssa Del Bono, Laura
correlatore Dott.ssa Del Bono, Laura
Keywords
- gut microbiota.
- HPV
- Huma Papillomavirus
- microbiota intestinale
Graduation session start date
25/11/2022
Availability
Withheld
Release date
25/11/2062
Summary
L’infezione da HPV rappresenta la condizione più frequentemente diffusa tra la popolazione sessualmente attiva, acquisita in modo silente e riscontrata per il manifestarsi di lesioni oppure reperto incidentale nel corso di controlli in follow-up. Si tratta del più studiato riscontro diagnostico in campo ginecologico, sebbene ultimamente maggiore interesse per l’argomento sorga anche in ulteriori campi specialistici, quali l’Otorinolaringoiatria e la Proctologia. La persistenza e l’integrazione di HPV possono portare all’ evoluzione maligna dell’infezione, sebbene ormai numerosi studi dimostrino che la sola presenza di HPV non sia sufficiente per condurre all’eventuale evoluzione maligna. Difatti, l’ipotesi avanzata in molte ricerche asserisce che la disbiosi locale possa avere effetti sulla progressione a tumore e sulla risposta ad eventuali trattamenti. In quest’ottica, questo studio preliminare raccoglie dati relativi a pazienti afferenti all’Ambulatorio Multidisciplinare della Azienda Ospedaliera Universitaria Pisana, esaminandoli in maniera prospettica e raccogliendo informazioni su una popolazione non clusterizzata. I risultati hanno associato il referto relativo alla positività o meno ad HPV su prelievo anale principalmente e la valutazione del microbiota intestinale da tampone rettale. Ulteriori correlazioni si sono effettuate con i dati clinici e laboratoristici a disposizione.
HPV infection is the most common condition among the sexually active population, acquired silently and found for the onset of lesions or incidental findings during follow-up checks. HPV infection is the most studied diagnostic finding in the gynecological field, but recently has received interest in other specialized fields, such as Otorhinolaryngology and Proctology. The persistence and integration of HPV can lead to the malignant evolution of the infection, although numerous studies showed that the sheer presence of HPV is not sufficient to lead to any malignant evolution. In fact, varios studies have suggested that local dysbiosis can have a role in the tumor progression and its response to treatments. With this in mind, this preliminary study collects data relating to patients belonging to the Multidisciplinary Outpatient Clinic of the Azienda Ospedaliera Universitaria Pisana, examining them prospectively and collecting information on a non-clustered population. We showed association between HPV positivity, mainly based on anal swab, and the intestinal microbiota obtained from rectal swab. Other correlations were studied between microbiota and other available clinical and laboratory data.
HPV infection is the most common condition among the sexually active population, acquired silently and found for the onset of lesions or incidental findings during follow-up checks. HPV infection is the most studied diagnostic finding in the gynecological field, but recently has received interest in other specialized fields, such as Otorhinolaryngology and Proctology. The persistence and integration of HPV can lead to the malignant evolution of the infection, although numerous studies showed that the sheer presence of HPV is not sufficient to lead to any malignant evolution. In fact, varios studies have suggested that local dysbiosis can have a role in the tumor progression and its response to treatments. With this in mind, this preliminary study collects data relating to patients belonging to the Multidisciplinary Outpatient Clinic of the Azienda Ospedaliera Universitaria Pisana, examining them prospectively and collecting information on a non-clustered population. We showed association between HPV positivity, mainly based on anal swab, and the intestinal microbiota obtained from rectal swab. Other correlations were studied between microbiota and other available clinical and laboratory data.
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