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Digital archive of theses discussed at the University of Pisa

 

Thesis etd-10252022-111023


Thesis type
Tesi di specializzazione (4 anni)
Author
ROMEO, FRANCESCA
URN
etd-10252022-111023
Thesis title
General psychopathology severity in psychogeriatric patients with Mild Behavioral Impairment
Department
MEDICINA CLINICA E SPERIMENTALE
Course of study
PSICHIATRIA
Supervisors
relatore Perugi, Giulio
correlatore Lattanzi, Lorenzo
Keywords
  • mild behavioral impairment
  • apathy
  • global functioning
  • old age
  • neuropsychiatric symptoms
Graduation session start date
14/11/2022
Availability
Withheld
Release date
14/11/2092
Summary
Background: Neuropsychiatric symptoms (NPS) are frequent in dementia and in pre-dementia states. They were included in the construct of Mild Behavioral Impairment (MBI), but literature on the pre-dementia stages is still limited. We investigated the relationship between MBI and both clinical presentation and functioning in an elderly population referred to outpatient psychiatric service. Methods: A prospective longitudinal study was performed in a sample of 144 patients aged ≥ 50 with either psychiatric disorders (PSY), MBI or dementia (DEM). Changes in symptoms severity and functioning were assessed at least after three-months of follow-up. We evaluated MBI symptoms, cognitive performances, severity of psychopathology, and overall functioning using MBI-C, MMSE, BPRS, CGI, GAF scales. Results: DEM patients reported the highest BPRS-Total, Psychosis, Activation, Negative Symptoms scores; MBI patients showed higher BPRS-Negative Symptoms than PSY ones. At follow-up, only PSY showed reduced BPRS and CGI-S, and increased GAF scores. No significant changes resulted at BPRS, CGI and GAF scores in MBI patients. Conclusions: The presence of MBI affects both clinical and functional short-term outcomes. The recognition of patients with MBI symptoms, including apathy, might be useful for the differential diagnosis with chronic psychiatric symptoms and for the early detection of individuals at risk of dementia.
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