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Digital archive of theses discussed at the University of Pisa

 

Thesis etd-10252019-194714


Thesis type
Tesi di specializzazione (4 anni)
Author
SCHIRRU, ALESSANDRO
URN
etd-10252019-194714
Thesis title
The influence of CLOCK and Per2 genes in an Italian cohort of Alzheimer's Disease and Mild Cognitive Impairment patients: genetic and actigraphic data
Department
MEDICINA CLINICA E SPERIMENTALE
Course of study
NEUROLOGIA
Supervisors
relatore Prof. Siciliano, Gabriele
correlatore Dott.ssa Bonanni, Enrica
Keywords
  • circadian rhythms
  • ritmi circadiani
  • Alzheimer disease
  • mild cognitive mpairment
  • actigrafo
  • actigraphy
  • geni clock
  • clock genes
  • sonno
  • sleep
Graduation session start date
14/11/2019
Availability
Withheld
Release date
14/11/2089
Summary
The interest in chronobiology has raised in recent years, also thanks to the contribution of molecular biology in detecting the genes responsible for circadian rhythms, because the understanding of mechanisms underlying circadian rhythms and their changes in normal ageing and pathologies like neurodegeneration could provide new approaches in diagnosing and preventing these disorders.
The aims of the study were (1) to determinethe incidence of circadian locomotor output cycle kaput (CLOCK) gene T3111C and PER2 gene C111G polymorphisms in a cohort of Alzheimer’s disease and Mild Cognitive Impairment patients compared to healthy age matched controls, (2) to evaluate sleep parameters and circadian rhythms in the same population by actigraphy.
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