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Digital archive of theses discussed at the University of Pisa

 

Thesis etd-10232023-163924


Thesis type
Tesi di specializzazione (4 anni)
Author
NONNE, GIOVANNA
URN
etd-10232023-163924
Thesis title
Discriminating between Brain-first and Body-first Parkinson's Disease using radiomics-enhanced dopamine transporter SPECT image analysis and DaTQUANT semi-quantitative output data.
Department
RICERCA TRASLAZIONALE E DELLE NUOVE TECNOLOGIE IN MEDICINA E CHIRURGIA
Course of study
MEDICINA NUCLEARE
Supervisors
relatore Prof. Volterrani, Duccio
correlatore Dott.ssa Aghakhanyan, Gayane
Keywords
  • Parkinson's Disease
  • radiomics
  • 123-I-FP-CIT
  • Single-photon emission computed tomography
Graduation session start date
06/11/2023
Availability
Withheld
Release date
06/11/2093
Summary
Recently it has been hypothesized that Parkinson’s Disease comprises two subtypes: a brain-first (top-down) type, where alpha-synuclein pathology initially arises in the brain with secondary spreading to the peripheral autonomic nervous system, and a body-first (bottom-up) type, where the pathology originates in the enteric or peripheral autonomic nervous system and then spreads to the brain. Our study aims to reveal possible differences between the two subtypes using radiomics-enhanced dopamine transporter SPECT image analysis and DaTQUANT semi-quantitative output data.
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