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Digital archive of theses discussed at the University of Pisa

 

Thesis etd-10232019-100752


Thesis type
Tesi di specializzazione (4 anni)
Author
MAIELLO, MARCO
URN
etd-10232019-100752
Thesis title
Developmental Trajectories of Adult ADHD: From Emotional Dysregulation To Bipolarity
Department
MEDICINA CLINICA E SPERIMENTALE
Course of study
PSICHIATRIA
Supervisors
relatore Prof. Perugi, Giulio
relatore Prof. Maremmani, Icro
Keywords
  • emotional dysregulation
  • bipolar disorder
  • neurodevelopment
  • ADHD
Graduation session start date
12/11/2019
Availability
Withheld
Release date
12/11/2089
Summary
Attention Deficit/Hyperactivity Disorder (ADHD) in adulthood is characterized by an heterogeneous and atypical presentation, notably with less externalizing and hyperactive symptoms and with a higher rate of psychiatric comorbidities. From a clinical perspective, the symptomatologic dimension that is more frequently associated with adult ADHD is Emotional Dysregulation (ED), often displaying with low frustration tolerance, impulsivity, irritability and affect and mood lability. This this mood instability, from a personological standpoint, is typically recognized as Borderline Personality Disorder (BPD) or, due to worsening of symptoms, as a disorder of the bipolar spectrum. To date there are limited investigations into the expressions of Adult ADHD, and the dimensional correlates and medical outcomes. The aim of this study is to explore the correlates of the presence of low and high level of ED and BPD in a sample of adult ADHD patients and their relationship with clinical, temperamental characteristics and bipolar spectrum comorbidities. The multiple logistic regression analyses, showed that the variables mostly associated with the RIPoSt Total score (higher ED) were female gender (p=0.011), cyclothymic (p<0.001) and irritable temperaments (p=0.004) and HCL-32 total score (p=0.012). Comparing ADHD patients with BPD (BPD+) and without BPD (BPD-) we carried a multiple logistic regression which has shown that bipolar spectrum (p=0.006), female gender (p=0.002), BPRS total score (p=0.001) and HCL-32 total score (p=0.026) were mostly associated with BPD+ patients. Comparing ADHD patients with BD (BD+) and without BD (BD-) we carried a multiple logistic regression which has shown that borderline personality disorder was mostly associated with BPD+ patients (p=0.026).
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