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ETD

Digital archive of theses discussed at the University of Pisa

 

Thesis etd-10202022-110602


Thesis type
Tesi di specializzazione (4 anni)
Author
MAGGIO, CHIARA
URN
etd-10202022-110602
Thesis title
Relationship between behavioural and psychological symptoms of dementia and amyloid burden in patients with AD
Department
RICERCA TRASLAZIONALE E DELLE NUOVE TECNOLOGIE IN MEDICINA E CHIRURGIA
Course of study
MEDICINA NUCLEARE
Supervisors
relatore Volterrani, Duccio
correlatore Dott.ssa Aghakhanyan, Gayane
Keywords
  • amyloid deposits
  • beta-amyloid protein
  • positron emission tomography
  • behavioural and psychological symptoms of dementia
  • alzheimer's disease
  • mild cognitive impairment
  • standardized uptake value ratio
Graduation session start date
04/11/2022
Availability
Withheld
Release date
04/11/2092
Summary
Behavioral and psychological symptoms of dementia (BPSD) are frequent features of Alzheimer’s Disease (AD) and of Mild Cognitive Impairment (MCI) with 35% to 75% patients affected by MCI experiencing at least one neuropsychiatric symptom with depression, apathy and anxiety being the most prevalent. Previous studies investigating the relationship between BPSD and AD pathology (Aβ deposition and tau pathology) are not univocal some showing a correlation between BPSD and Aβ deposition, others not confirming this association and demonstrating that BPSD seem to be predominantly related to tau pathology Our study aim to reveal possible differences in cerebral beta-amyloid deposition, as measured by [18F]-Florbetapir-PET quantitative uptake, between AD and MCI due to AD patients with and without BPSD.
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