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Digital archive of theses discussed at the University of Pisa

 

Thesis etd-10172020-085621


Thesis type
Tesi di specializzazione (4 anni)
Author
MOROLLA, DAVIDE
URN
etd-10172020-085621
Thesis title
Rheumatic Heart Disease In Eritrean Schoolchildren: Results From An International Cooperation Project
Department
PATOLOGIA CHIRURGICA, MEDICA, MOLECOLARE E DELL'AREA CRITICA
Course of study
MALATTIE DELL'APPARATO CARDIOVASCOLARE
Supervisors
relatore Prof. Pedrinelli, Roberto
relatore Dott.ssa Assanta, Nadia
Keywords
  • onlus
  • RHD
  • rheumatic heart disease
  • studenti
  • malattia reumatica
  • Eritrea
  • ecocardiografia
  • cooperazione
  • cardiologia
  • cardiologia pediatrica
  • Africa
Graduation session start date
06/11/2020
Availability
Full
Summary
Background
Rheumatic Heart Disease is one of the main non-communicable diseases in low-to-middle income countries and represents the second leading cause of cardiovascular morbidity and mortality in endemic areas. To date, no cross-sectional surveys have been conducted in Eritrea. The aim of this study is to determine the prevalence of rheumatic heart disease in eritrean schoolchildren.
Methods
Randomly selected schoolchildren from 4 to 19 years of age in Eritrea were screened for rheumatic heart disease according to standard echo-cardiographic criteria.
Results
Echocardiographic screening detected rheumatic heart disease in 390 of 8945 schoolchildren. The overall prevalence of rheumatic heart disease was 43.6 cases per 1000 (95% CI, 39.4 to 47.8). The prevalence was higher in rural areas compared to urban areas (odds ratio 2.2; 95% CI, 2.8 to 1.7; p < 0.0001) and increased with age (chi-squared for trend 12.44; p = 0.0004). The mitral valve and aortic valve were involved in the 97% and 11,3% of cases, respectively. Congenital heart disease was detected in 103 children and the prevalence was 11.5 cases per 1000 (95% CI, 13.7 to 9.3).
Conclusions
Echocardiographic screening revelead for the first time the prevalence of rheumatic heart disease in eritrean schoolchildren. The prevalence was one of the highest in the world. These results may have important public health implications and may represent a first step for the implementation of a national prevention program.
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