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Digital archive of theses discussed at the University of Pisa

 

Thesis etd-10162023-174053


Thesis type
Tesi di specializzazione (4 anni)
Author
GODDI, ANTONIO
URN
etd-10162023-174053
Thesis title
The prognostic value of radiomic features in liver-limited metastatic colorectal cancer patients from the TRIBE2 study
Department
RICERCA TRASLAZIONALE E DELLE NUOVE TECNOLOGIE IN MEDICINA E CHIRURGIA
Course of study
RADIODIAGNOSTICA
Supervisors
relatore Prof. Neri, Emanuele
Keywords
  • liver-limited metastatic colorectal cancer
  • radiomics features
  • prognostic factor
  • first-line chemotherapy plus bevacizumab
Graduation session start date
07/11/2023
Availability
Withheld
Release date
07/11/2026
Summary
Aims
Evaluating the prognostic role of radiomic features in liver-limited mCRC treated with first-line therapy at baseline and best response among patients undergoing resection.

Patients and methods
Among patients enrolled in TRIBE2 (NCT02339116), the association of clinical and radiomic data, extracted by SOPHiA-DDM™, with PFS/OS in the overall population and with DFS/post-resection OS in those undergoing resection was investigated.

Results
Among 98 patients, radiomic parameters improved the prediction accuracy of our model for OS (AUC=0.83, sensitivity=0.85, specificity=0.73, accuracy=0.78), but not PFS.
Of 46 resected patients, small distance high grey level emphasis was associated with shorter DFS, high grey level zone emphasis/higher kurtosis with shorter post-resection OS.

Conclusions
Radiomic features should be implemented in tools of outcome prediction for LL-mCRC.





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