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Digital archive of theses discussed at the University of Pisa

 

Thesis etd-10162022-201159


Thesis type
Tesi di specializzazione (4 anni)
Author
FERRINI, ERICA
URN
etd-10162022-201159
Thesis title
Analysis of corneal microstructural changes with in vivo confocal microscopy in keratoconus patients after corneal collagen cross-linking and correlation with clinical outcomes
Department
PATOLOGIA CHIRURGICA, MEDICA, MOLECOLARE E DELL'AREA CRITICA
Course of study
OFTALMOLOGIA
Supervisors
relatore Prof. Figus, Michele
relatore Dott.ssa Gabbriellini, Giovanna
Keywords
  • cornea
  • keratoconus
  • corneal collagen cross-linking
  • in vivo confocal microscopy
  • langerhans cells
  • allergy
  • eye rubbing
  • quality of life
Graduation session start date
03/11/2022
Availability
Withheld
Release date
03/11/2062
Summary
The corneal microstructural features and in particular Langerhans cells density and morphology were assessed in consecutive patients undergoing corneal collagen cross-linking for progressive keratoconus. In our previous research we highlighted a reduction in eye rubbing behavior in keratoconus patients after cross-linking. Corneal cross-linking is known to produce typical ultrastructural changes in treated keratoconic corneas, but the effect of the treatment on Langerhans cells and its correlation with clinical outcomes haven't yet been investigated. Langerhans cells are dendritic presenting cells of the cornea and are typically activated in inflammatory and allergic environments, such as those associated with eye rubbing behavior. Quality of life, eye rubbing behavior, clinical features were assessed and in vivo confocal microscopy was performed in patients before and after treatment. Several correlations were noted between clinical and ultrastructural parameters. Among those, significant correlation between eye rubbing behavior and Langerhans cells density and morphology before treatment was demonstrated. These variables also showed significant reduction after treatment.
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