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Digital archive of theses discussed at the University of Pisa

 

Thesis etd-10162018-114116


Thesis type
Tesi di laurea magistrale LM5
Author
NASTARANTEHRANI, MARJAN
URN
etd-10162018-114116
Thesis title
Nutraceutical approach to the cardiometabolic risk: effects of Eruca sativa Mill. in an experimental model of dyslipidemia
Department
FARMACIA
Course of study
FARMACIA
Supervisors
relatore Prof. Calderone, Vincenzo
relatore Prof.ssa Testai, Lara
correlatore Dott.ssa Piragine, Eugenia
Keywords
  • glucosinolate
  • glucoraphanine
  • glucoerucin
  • Eruca sativa Mill.
  • dyslipidemia
  • citrate synthase
  • cardiovascular diseases
  • cardiometabolic risk
  • Brassicaceae
  • adipose tissue
  • in vivo experimental
  • sulforaphanine
Graduation session start date
07/11/2018
Availability
Full
Summary
Cardiometabolic risk is one of the main factor of cardiovascular diseases (CVD), such as htpertension, myocardial infarction and brain stoke. Recently, many studies have demonstrated that several nutraceuticals are foods normally used in our diet that exert beneficial effects in our organism. The botanical family of Brassicaceae includes several edible plants such as Brassica Oleracea, Brassica Rapa, Brassica Napus, endowed with important antitumoral, antidiabetic, antiflammatory, antiplatelet and cytoprotective properties. These properties are likely to be associated with the presence of sulfur secondary mmetabolities, named Glucosinolates. In this thesis we focused on the effects of Eruca sativa Mill. on an in vivo experimental model of dyslipidemia. BALB-C male mice were used and were fed for 10 weeks with standard diet (control group), or with an high fat diet (HF) enriched with an Eruca sativa Mill. extract (0.75% p/p), titled in glucoerucin and Glucoraphanine. During the experimetal procedure we regulary monitored food intake, water intake and body weight of each mouse. At the end of the treatment, we acquired the parameters related to the cardiometabolic risk such as plasma HDL/LDL, total cholesterol, triglycerides and glycemia.
Heart, brain, liver, adipose tissue and femurs were also collected for furthur histological and functional investigations.
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