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Tesi etd-10162018-114116

Thesis type
Tesi di laurea magistrale LM5
Nutraceutical approach to the cardiometabolic risk: effects of Eruca sativa Mill. in an experimental model of dyslipidemia
Corso di studi
relatore Prof. Calderone, Vincenzo
relatore Prof.ssa Testai, Lara
correlatore Dott.ssa Piragine, Eugenia
Parole chiave
  • dyslipidemia
  • adipose tissue
  • in vivo experimental
  • citrate synthase
  • cardiovascular diseases
  • cardiometabolic risk
  • glucoerucin
  • Brassicaceae
  • Eruca sativa Mill.
  • glucosinolate
  • sulforaphanine
  • glucoraphanine
Data inizio appello
Secretata d'ufficio
Riassunto analitico
Cardiometabolic risk is one of the main factor of cardiovascular diseases (CVD), such as htpertension, myocardial infarction and brain stoke. Recently, many studies have demonstrated that several nutraceuticals are foods normally used in our diet that exert beneficial effects in our organism. The botanical family of Brassicaceae includes several edible plants such as Brassica Oleracea, Brassica Rapa, Brassica Napus, endowed with important antitumoral, antidiabetic, antiflammatory, antiplatelet and cytoprotective properties. These properties are likely to be associated with the presence of sulfur secondary mmetabolities, named Glucosinolates. In this thesis we focused on the effects of Eruca sativa Mill. on an in vivo experimental model of dyslipidemia. BALB-C male mice were used and were fed for 10 weeks with standard diet (control group), or with an high fat diet (HF) enriched with an Eruca sativa Mill. extract (0.75% p/p), titled in glucoerucin and Glucoraphanine. During the experimetal procedure we regulary monitored food intake, water intake and body weight of each mouse. At the end of the treatment, we acquired the parameters related to the cardiometabolic risk such as plasma HDL/LDL, total cholesterol, triglycerides and glycemia.
Heart, brain, liver, adipose tissue and femurs were also collected for furthur histological and functional investigations.