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Tesi etd-10142019-225914


Thesis type
Tesi di specializzazione (4 anni)
Author
TERLIZZESE, GIUSEPPE
URN
etd-10142019-225914
Title
Long-Term Durability of Transcatheter Aortic Valve Prostheses: Echocardiographic Follow Up Beyond Five Years
Struttura
PATOLOGIA CHIRURGICA, MEDICA, MOLECOLARE E DELL'AREA CRITICA
Corso di studi
MALATTIE DELL'APPARATO CARDIOVASCOLARE
Supervisors
relatore Prof. Pedrinelli, Roberto
relatore Prof.ssa Petronio, Anna Sonia
Parole chiave
  • durability
  • long-term outcomes
  • TAVI
Data inizio appello
04/11/2019;
Consultabilità
Secretata d'ufficio
Data di rilascio
04/11/2089
Riassunto analitico
Aims: to determine functional changes of balloon-expandable, self expandable and mechanically expanding transcatheter valve prosthesis, with long-term echocardiography follow-up beyond 5 years according to the 2017 EAPCI/ESC/EACTS definition of valve durability.
Methods and results: between 2007 and 2014, 52 consecutive patients (mean age 82,17±1,12 years) were enrolled in our prospective single-centre registry; median follow-up was 6.4 years. Mean pressure gradients remained stable over time and structural valve deterioration occurred in 4 patients (7,7%). There was one case (1.9%) of severe SVD (new severe intraprosthetic aortic regurgitation). There were 3 cases (5.8%) of moderate SVD (mean 5.7 years post-implantation, range from 5 to 6.4 years). 1 case was due to new moderate AR and 2 cases to restenosis (increase in mean gradient ≥10mmHg).
Conclusions: Long-term transcatheter aortic valve function is excellent. In our study, 92% of patients remained free of SVD between 4.4 and 11 years post-implantation. The incidence of severe SVD was <2%. Moderate SVD occurred in only 3 patients.
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