• catalisi
• chimica organica
• reazioni a flusso
• stereoselettività

This work has been aimed to the study of insoluble polymer-bound (IPB) chiral organocatalysts to be used under continuous flow or batch conditions for enantioselective transformations. For the preparation of IPB chiral organocatalysts inside microreactors two different strategies were taken into consideration: (a) bottom-up approach, where proline derivatives were supported by CuAAC on methacrylic polymer brushes, grown by atom transfer radical polymerization (ATRP) on the inner walls of a microchip; (b) copolymerization of proline-bearing styrenic monomer with styrene and divinylbenzene (DVB) to produce a resin monolith within an empty HPLC column.
For the use in batch reactions we developed a novel pyrrolidine-sulfonamide organocatalyst supported by CuAAC on commercial Merrifield resin.