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Tesi etd-08102020-155533


Thesis type
Tesi di specializzazione (4 anni)
Author
LAZIO, MARIA SILVIA
URN
etd-08102020-155533
Title
Feasibility of OPHL in selected advanced laryngeal cancers: functional and oncological outcomes of a Tertiary Center
Struttura
PATOLOGIA CHIRURGICA, MEDICA, MOLECOLARE E DELL'AREA CRITICA
Corso di studi
OTORINOLARINGOIATRIA
Supervisors
relatore Prof. Gallo, Oreste
correlatore Dott. Ansarin, Mohssen
Parole chiave
  • laryngeal function preservation
  • laryngeal cancer
  • advanced laryngeal cancer
  • OPHL
  • Organ preservation
Data inizio appello
02/09/2020;
Consultabilità
Secretata d'ufficio
Data di rilascio
02/09/2090
Riassunto analitico
Laryngeal cancer is a relevant clinical problem, in fact despite all the advances in laryngeal oncology, survival rate for advanced stages (III-IV) remains<50%. The organ preservation strategy, surgical (OPHL) and non surgical (CRT), demonstrated that larynx preservation is feasible. The aim of this study was to assess the efficacy of OPHL +/- adjuvant (adj) therapy for advanced stage of laryngeal cancer, evaluating the laryngeal function and survival of the patients (pts) and comparing the outcomes with similar reported in literature. We analyzed a retrospective cohort of pts treated with OPHL (with or without Neck Dissection and adj therapy) at the Department of Otolaryngology & Head and Neck Surgery of the European Institute of Oncology. 110 cases were included. The 5-year Overall Survival, Disease Specific Survival, Disease Free Survival, Laryngeal Free Survival and Laryngeal Function Preservation Free Survival were 67%, 81%, 57%, 65%, and 66%, respectively. The local, regional and loco-regional control rate were: 96.4%, 95.4% and 90%. The great part of our pts (95.5%) maintained a functional larynx in place and pts underwent OPHL plus adj therapy achieved better oncological outcomes compared with pts that received CRT in literature. We could say that an adequate recruitment of patients and their tumors extension, could permit a proper conservative surgical treatment also for pT3 and selected pT4a advanced laryngeal cancers with good functional and oncological results.
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