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Tesi etd-06302014-103458


Thesis type
Tesi di laurea specialistica LC6
Author
MONTANO, VINCENZO GIOVANNI
URN
etd-06302014-103458
Title
Trombosi venose cerebrali: caratterizzazione clinico patogenetica di una coorte di 43 pazienti afferenti alla Clinica Neurologica Pisana
Struttura
RICERCA TRASLAZIONALE E DELLE NUOVE TECNOLOGIE IN MEDICINA E CHIRURGIA
Corso di studi
MEDICINA E CHIRURGIA
Commissione
relatore Prof. Bonuccelli, Ubaldo
Parole chiave
  • stroke
  • stati trombofilici
  • fattori di rischio
  • contraccettivi orali
  • trombosi venose cerebrali
Data inizio appello
22/07/2014;
Consultabilità
completa
Riassunto analitico
Cerebral sinus venous thrombosis (CSVT) is a rare condition representing the 0.5-1% of all stroke<br>cases which can have serious consequences. Early diagnosis and complete screening for acquired or<br>inherited risk factors is crucial for decreasing morbidity and mortality. We have investigated clinical and etiological factors in an Italian cohort of 43 patients with CSVT. Common presentation complaints were headache (81.4%), focal signs (20.9%), vomiting (11.6%), and seizures (6.9%). Acquired or inherited conditions were observed in more than 80% of cases. The commonest etiological factors were contraceptives (74.1% of females), congenital thrombophilia (34.9%), infections and dysthyroidism (16.3%), iperhomocysteinemia (9.3%), migraine (11.6%), cranial trauma (9.3%), and chronic myeloproliferative diseases (11.6%). Outcome was favourable in more than 80% of patients. Early diagnosis and anticoagulant treatment may decrease mortality and/or morbidity rates related with CVST in these patients. Thrombophilic abnormalities, either inherited or acquired, are worthy to be widely investigated.
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