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ETD

Digital archive of theses discussed at the University of Pisa

 

Thesis etd-06272007-180215


Thesis type
Tesi di dottorato di ricerca
Author
Plantinga, Yvonne
URN
etd-06272007-180215
Thesis title
The effects of physical activity, antioxidants and dietary intake on arterial stiffness and endothelial function in hypertensive and normotensive subjects
Academic discipline
MED/11
Course of study
FISIOPATOLOGIA MEDICA E FARMACOLOGIA
Supervisors
Relatore Prof. Taddei, Stefano
Keywords
  • antioxidants
  • arterial stiffness
  • dietary intake
  • endothelial function
  • hypertension
  • metabolic syndrome
  • physical activity
Graduation session start date
30/03/2007
Availability
Full
Summary
This thesis describes that essential hypertension is a powerful predictor of cardiovascular disease, accompanied by endothelial dysfunction and increased arterial stiffness. In the studied population, the presence of the metabolic syndrome in patients with overt disease such as hypertension was not associated with ulterior increase in endothelial dysfunction or arterial stiffness. Furthermore, regular physical activity was associated only with a lower augmentation index in normotensive subject but not in hypertensive patients. We found an association between regular high intensity endurance exercise, antioxidant capacity and preserved endothelial function in healthy older men, confirming the important mechanism of antioxidant defenses against oxidative stress. In this line we also showed a beneficial effect of vitamin antioxidant supplementation on arterial stiffness and endothelial function in essential hypertensive patients after 8 weeks of vitamin C and E supplementation. This association was not observed in the evaluation of regular intake of antioxidants.
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