ETD system

Electronic theses and dissertations repository

 

Tesi etd-06232016-084428


Thesis type
Tesi di specializzazione (5 anni)
Author
CECCARELLI, ALESSIA
URN
etd-06232016-084428
Title
MRI evaluation of lung involvement on the basis of CT scans in systemic sclerosis
Struttura
RICERCA TRASLAZIONALE E DELLE NUOVE TECNOLOGIE IN MEDICINA E CHIRURGIA
Corso di studi
RADIODIAGNOSTICA
Commissione
relatore Prof. Caramella, Davide
relatore Prof. Neri, Emanuele
Parole chiave
  • MRI
  • LUNG
Data inizio appello
09/07/2016;
Consultabilità
parziale
Data di rilascio
09/07/2019
Riassunto analitico
Objectives<br>The aim of this study was to assess resonance signal of lung fields, using Cardiac-MRI performed to detect myocardial involvement in patients affected by systemic sclerosis.<br>Materials and methods<br>Retrospectively we analyzed HRCT scans performed on 40 patients with a diagnosis of systemic sclerosis, who underwent a HRCT scan and MRI (Cardiac-MRI) the same day.<br>HRCT scans were scored by two radiologists on the basis of &#34;Scleroderma lung study”, a semi-quantitative scoring to evaluate the four categories of parenchymal abnormality (pure Ground Glass Opacities, lung fibrosis including thickened reticular markings, bronchiectasis, bronchioloectasis and honeycombing ).<br>The MRI abnormalities were evaluated in comparison with HRCT observations utilized as reference standard.<br>A STIR and T1-weighted (before and after Gadolinium administration) sequences were performed; patient images were analyzed using a software (HIPPO SW), that allows to draw one or more regions of interest (ROI) manually and to obtain with a curve-fitting technique to estimate STIR and T1 values in the ROI; the ROI(s) were drawn in anatomical sections corresponding to normal lung parenchyma or scleroderma lung abnormalities as demonstrated by HRCT scan. STIR and T1 values so obtained were compared.<br> Results<br>With the patient in supine position, the posterior dependent areas presented higher signal than anterior non dependent areas. We obtained a significantly different signal between dependent areas and pathological interstitial pattern , using both STIR and T1-weighted pre and post-contrast sequences, whereas no significant signal difference between specific interstitial patterns (GG, RET and GG+/-RET) was demonstrated.<br> Conclusion<br>MRI with STIR and T1- weighted sequences, if performed to assess cardiac involvement, can be used as an alternative to HRCT to reduce radiation exposure, especially in young patients; it is amenable to detect lung interstitial involvement in Systemic sclerosis, but not to recognize specific interstitial pattern such as GG or GG and RET.<br>
File