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Tesi etd-06202016-110113


Thesis type
Tesi di specializzazione (5 anni)
Author
LU, FEI
URN
etd-06202016-110113
Title
Impact of Contractile Reserve on Functional Recovery after TAVI in Patients with Aortic Stenosis and Impaired Left Ventricular Function: a Low Dose Dobutamine Echo Study
Struttura
PATOLOGIA CHIRURGICA, MEDICA, MOLECOLARE E DELL'AREA CRITICA
Corso di studi
MALATTIE DELL'APPARATO CARDIOVASCOLARE
Commissione
relatore Prof. Marzilli, Mario
relatore Prof.ssa Petronio, Anna Sonia
Parole chiave
  • TAVI
  • Functional Recovery
  • Contractile Reserve
  • Dobutamine
Data inizio appello
06/07/2016;
Consultabilità
parziale
Data di rilascio
06/07/2019
Riassunto analitico
Transcatheter aortic valve implantation (TAVI) has broadened treatment options for high-risk patients with severe aortic stenosis (AS). However, 1-year mortality after TAVI in patients with left ventricular dysfunction has been described to be relative high. Furthermore, there were a number of such patients who received TAVI who, although alive over 1 year, continued to have very poor quality of life, with significant heart failure symptoms and functional limitation. To date, however, there has been little guidance as to how best to identify patients with poorer outcomes. Few studies were published about functional recovery immediate after TAVI in aortic stenosis patients with impaired left ventricular (LV) function and little is known the impact of immediate functional recovery on further functional improvement. It has been reported that the patients with poor outcomes are partly due to lack of left ventricular function recovery after TAVI and data is limited and controversial on the relationship between the presence of contractile reserve at dobutamine stress echocardiography and function recovery post-intervention. <br>The goals of the present study therefore are: 1. to evaluate the prevalence of immediate improvement in LV function post-TAVI and its impact on further functional recovery at 3-month follow-up in AS patients with impaired LV function undergoing TAVI; 2. To clarify the predictive value of LV contractile reserve assessed by low dose DSE on short term functional recovery in such patients.
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