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Tesi etd-06182014-152410


Thesis type
Tesi di specializzazione (5 anni)
Author
LANDINI, LINDA
URN
etd-06182014-152410
Title
Effects of bariatric surgery on whole body and femoral adipose tissue insulin sensitivity
Struttura
MEDICINA CLINICA E SPERIMENTALE
Corso di studi
MEDICINA INTERNA
Commissione
relatore Taddei, Stefano
correlatore Ferrannini, Eleuterio
Parole chiave
  • insulin resistance
  • glucose-uptake
  • bariatric surgery
  • adipose tissue
  • insulin sensitivity
Data inizio appello
30/06/2014;
Consultabilità
completa
Riassunto analitico
The effect of weight reduction by dietary treatment does not reverse adipose tissue insulin resistance,as opposed to skeletal muscle in which it makes a big improvement. For this reason, bariatric surgery has gained increasing acceptance as a treatment for morbid obesity and co-morbid diseases. To the best of our knowledge, there is no evidence of how bariatric surgery modulates femoral adipose tissue glucose uptake. <br>In the present study we examine how bariatric surgery modifies femoral adipose tissue glucose uptake both in fasting condition and during euglycemic hyperinsulinemic clamp in severely obese patients and healthy lean subjects using positron emission tomography (PET)at baseline and six months after bariatric surgery and to study if the changes in adipose tissue glucose uptake were related with the remission of diabetes.<br>
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