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Tesi etd-06152016-192409


Thesis type
Tesi di laurea magistrale LM6
Author
SESSO, GIANLUCA
email address
gianse91@gmail.com
URN
etd-06152016-192409
Title
Electrophysiological and micro-architectural features of sleep in children at high risk for depression
Struttura
RICERCA TRASLAZIONALE E DELLE NUOVE TECNOLOGIE IN MEDICINA E CHIRURGIA
Corso di studi
MEDICINA E CHIRURGIA
Supervisors
relatore Prof. Faraguna, Ugo
Parole chiave
  • spindles
  • CAP
  • children
  • depression
  • sleep
Data inizio appello
19/07/2016;
Consultabilità
Parziale
Data di rilascio
19/07/2019
Riassunto analitico
Major depressive disorder is very common worldwide and its clinical importance reveals
the need for a global attention focused at identifying early risk biomarkers of the disorder.
Among these, sleep alterations have recently emerged as potential markers of depression
and other psychiatric conditions. A large body of literature has documented that
familiarity is a major component of the susceptibility of MDD and depression is more
likely to occur among the offspring of depressed mothers. Intriguingly, sleep in children
at high risk for depression has only scarcely been evaluated and research on this topic is
still at an early stage. For these reasons, the present study was aimed at comparing
electrophysiological features and CAP micro-architecture of sleep between a group of
twenty children born to mothers with MDD and a group of eleven sex- and age-matched
controls. Our most relevant results were a reduction of low-frequency spindle activity and
related spatio-temporal characteristics and an altered distribution of CAP phase A
subtypes in high-risk children. Our hypothesis is that the existence of a predisposing
genetic programming for depression may trigger the development of a neuronal circuitry
with limited spindles generation and increased cerebral arousability; this would produce
functional anomalies in brain maturation, thus resulting in an altered cortical plasticity
that could in turn represent a pathogenic factor for major depression.
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