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Digital archive of theses discussed at the University of Pisa

 

Thesis etd-06142021-104127


Thesis type
Tesi di laurea magistrale LM5
Author
CAFA', ELIANA
URN
etd-06142021-104127
Thesis title
Sintesi di nuovi analoghi della Tizoxanide con potenziale attivita antivirale
Department
FARMACIA
Course of study
CHIMICA E TECNOLOGIA FARMACEUTICHE
Supervisors
relatore Prof. Minutolo, Filippo
relatore Prof.ssa Granchi, Carlotta
Keywords
  • N-hydroxyindole derivatives
  • antiviral drug
  • Nitazoxanide
  • COVID-19
Graduation session start date
07/07/2021
Availability
Withheld
Release date
07/07/2061
Summary
Synthesis of molecules with potential antiviral activity with N-hydroxindolic structure, bioisosterically similar to Nitazoxanide, an antiparasitic drug used in the treatment of COVID-19 for pharmacological repositioning. Nitazoxanide is an in vivo deacetylated prodrug to the active metabolite, Tizoxanide. The proposed mechanism of action for Tizoxanide and, consequently, for the newly synthesized derivatives, targets the human enzyme ERp57, also known as PDIA3, a thiol-disulfide oxidoreductase which constitutes a fundamental step for the activation of the viral F protein, responsible for the fusion of the virus to host cells.
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