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Digital archive of theses discussed at the University of Pisa

 

Thesis etd-06072023-090216


Thesis type
Tesi di laurea magistrale LM5
Author
EGIZZO, GAIA
URN
etd-06072023-090216
Thesis title
Lanthanide Glycoconjugated Complexes as Luminescent Molecular Probes
Department
FARMACIA
Course of study
CHIMICA E TECNOLOGIA FARMACEUTICHE
Supervisors
relatore Prof.ssa Di Bussolo, Valeria
relatore Dott. Di Pietro, Sebastiano
Keywords
  • luminescence
  • click chemistry
  • molecular probes
  • glycoconjugation
  • lanthanides
Graduation session start date
12/07/2023
Availability
Withheld
Release date
12/07/2026
Summary
Our work focuses on the synthesis of new glycoconjugated europium complexes of ligands based on a coordination motif known from the literature, which features a triazacyclononane azamacrocycle bearing charge-transfer antenna with strongly adsorbing p-substituted aryl-alkynyl group.The glycoconjugation approach was chosen to improve the aqueous solubility of the complexes and to make them able to interact with biological structures, such as the GLUTs transporters, which are overexpressed in tumor cells compared to healthy cells, due to the intense glycolytic activity which they perform (Warburg effect). Therefore, glycoconjugation represents a powerful tool to impart selectivity to therapeutic and molecular diagnostic agents, which are important especially in the diagnosis of early stage of cancer. The glycoconjugation was performed through the CuAAC click chemistry reaction.
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