• bio-hybrid
• cancer
• catheter
• drug
• therapy

The focus of this thesis is on the development of a biohybrid catheter, which combines biological and mechanical components to create a device capable of navigating through the complex and hard-to-reach parts of the human body. The main goal is to improve medical procedures and interventions by providing a more effective and minimally invasive tool.
To achieve this objective, several design parameters have been thoroughly examined. The dimensions of the catheter are crucial, as they need to be small enough to navigate through narrow passages, but also sturdy enough to withstand the forces encountered during insertion and movement. The elastic modulus, which determines the catheter's flexibility and resistance to deformation, has also been carefully considered.
In addition to the design parameters, the actuator used in the biohybrid catheter has been extensively studied. The actuator is responsible for the catheter's motion and deflection, enabling it to reach deep and challenging areas. By analyzing various actuator-related parameters, such as power requirements, control mechanisms, and range of motion, the researchers aimed to optimize the catheter's performance.
Another crucial aspect of the research is the characterization of the material used in the catheter. Both mechanical and biological properties have been evaluated to ensure that the material is suitable for its intended purpose. Mechanical properties, such as strength, flexibility, and durability, are essential to withstand the stresses and strains encountered during catheterization. Biological properties, on the other hand, involve compatibility with human tissues, minimizing the risk of adverse reactions or complications. Finally, the researchers have constructed prototypes of the biohybrid catheter in various sizes. These prototypes serve as practical implementations of the theoretical concepts and design considerations. By creating different-sized prototypes, the researchers can evaluate the feasibility and performance of the catheter under different scenarios and anatomical conditions. In conclusion, this thesis focuses on the development of a biohybrid catheter that combines a muscular actuator with careful design considerations and material characterization. By analyzing various parameters and constructing prototypes, the researchers aim to create a catheter capable of reaching deep and challenging areas of the human body while ensuring compatibility and effectiveness. This research has the potential to improve medical procedures and interventions, leading to better patient outcomes and a more advanced understanding of biohybrid technologies.