• beta-cariofillene
• dolore neuropatico
• mialgie.
• terapia del dolore

Background: Chronic pain is one of the most frequent disease symptoms and represents a global health problem with a considerable economic burding, affecting an estimated 20% to 30% of adults worldwide. The affectiveness of pharmacological treatments for chronic pain is often limited, and there is growing concern about the adverse effets of these treatment, including opioid dependance.
Non pharmacological approach to chronic pain may be an attractive alternative or adjunctive treatment. With this study, we describe the effectiveness of a multi-combined nutraceutical treatment on chronic pain syndrome as chronic neuropathic pain and fibromyalgia like symptomes.
Objective: To assess the analgesic effect of a multi-nutraceutical supplement of palmitoylethanolamide, ß - caryophyillene, carnosic acid and Commiphora Myrrha in terms of clinical outcome with improvement of evaluation scales, reduction of nitric oxyde levels, oxidative stress parameters (AOPP) and increase of the production of endogenous antioxidants (protein thiol groups and FRAP).
Selection Criteria: Randomised, double blind, active or alternative dietary supplement controlled trials investigating the use of the multiple dietary supplement (for at least six weeks' duration), for the treatment of chronic neuropathic pain or myalgia, with at least 10 participants per treatment group. Participants were adults aged 35 and over,
Methods: Twenty patients with diagnosis of chronic neuropathic pain or fibromyalgia-like symptomes were first of all characterized by sex, age, lifestyle, comorbilities and concomitants therapies.
The selected patients were evaluated with neurological examination, clinimetric evaluations scales focused on fatigue, pain and quality of life, CPK serum levels, electomiography (EMG) and electroneurography (ENG). Then, we measured the production of lactate, nitric oxyde and oxidative stress parameters during an aerobic multistage exercise tests performed on a bycicle ergometer, since the achievement of the 70% of the maximum theorical treshold calculated by sex, age and weight. Finally, after a six-week long add-on nutraceutical therapy, patients repeated the tests and clinical evaluations.
The control group (n=6) performed the same tests, but without consuming the supplement.