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Tesi etd-05232016-014155


Thesis type
Tesi di laurea magistrale LM5
Author
CAPPE', SARA
URN
etd-05232016-014155
Title
Nitrogen heterocycles derivatives as new modulators of endocannabinoid system and inhibitors of PDK1
Struttura
FARMACIA
Corso di studi
FARMACIA
Commissione
relatore Prof.ssa Manera, Clementina
relatore Prof.ssa Rapposelli, Simona
relatore Dott.ssa Gado, Francesca
Parole chiave
  • Anticancer agents
  • PDK1
  • CB2
  • Endocannabinoid System
Data inizio appello
08/06/2016;
Consultabilità
parziale
Data di rilascio
08/06/2019
Riassunto analitico
The cannabinoid system is a complex biochemical system involved in several physiological processes; It consists of CB1 and CB2 receptors, endogenous ligands and various enzymes with different functions. The activation of this system allows us to modulate the immune system, both central and peripheral level. The aim of my thesis was to synthesize compounds with activity on CB2 receptors, deepening relations business activities of the compounds of the series 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide. <br>Also, in my thesis, I have dealt of the chemical synthesis of new inhibitors of PDK1. The PI3K / PDK1 / Akt is one of signaling pathways, which regulates many crucial cellular functions in survival mechanisms and cell growth; numerous studies have helped define this signaling pathway as an important target for the development of new anticancer therapeutic strategies. <br>
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