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Tesi etd-05212013-134809


Tipo di tesi
Tesi di laurea magistrale
Autore
IACOVACCI, VERONICA
URN
etd-05212013-134809
Titolo
Design and development of a mechatronic implantable system for the refilling of artificial organs
Dipartimento
INGEGNERIA DELL'INFORMAZIONE
Corso di studi
INGEGNERIA BIOMEDICA
Relatori
relatore Dott. Ricotti, Leonardo
relatore Prof.ssa Menciassi, Arianna
Parole chiave
  • meccatronico
  • organi artificiali
  • pancreas
Data inizio appello
18/06/2013
Consultabilità
Non consultabile
Data di rilascio
18/06/2053
Riassunto
Mechatronic refilling device for long-term implantable artificial organs
Veronica Iacovacci, Leonardo Ricotti, Paolo Dario, and Arianna Menciassi
The BioRobotics Institute, Scuola Superiore Sant’Anna. Viale R.Piaggio 34, 56025 Pontedera (PI), Italy.
Objective: this work introduces a new paradigm for a lifelong-implanted completely automated artificial pancreas (AP) refilled by swallowable pills. We report data about the design and development of an implanted docking system and a refilling mechanism to be interfaced with the gastrointestinal tract, thus allowing long-term maintenance of a chronically implanted mechatronic AP.
Methods: the implanted docking system is based on a miniaturized Magnetic Switchable Device (MSD). Finite element method (FEM) analyses allowed to identify the most appropriate MSD design features and precision machining permitted its fabrication. A rotary DC motor assures MSD activation/deactivation. The swallowable capsule, carrying insulin and fabricated in polydimethilsiloxane, is provided with an RFID tag for its detection by the implanted system and with a ferromagnetic ring for docking. The refilling system is based on a miniaturized linear motor which pushes a needle into the duodenum/stomach internal lumen, in order to punch the docked capsule and to transfer the insulin from the capsule to the internal reservoir, thanks to a miniature pump. A dedicated passive valve integrated in the implantable system is the interface between the device and the body, thus allowing capsule punching and automatically closing after needle retraction.
Results: FEM analyses permitted to identify the best MSD shape which maximizes the contact area with the docked capsule. A Ni-Co-Fe alloy and an N52 NdFeB magnet were employed for achieving an attraction force of 11 N in the “ON” configuration and 1.41e-5 N in the “OFF” configuration. In addition, for a passive valve of 10 x 10 x 2.5 mm3, the maximum opening is ~ 1 mm, thus allowing the use of a 31G insulin needle.
Conclusion: The developed prototype requires further miniaturization, but it demonstrates the feasibility of a mechatronic implantable device for non invasive refilling of artificial organs based on swallowed cargos.
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