ETD

Digital archive of theses discussed at the University of Pisa

 

Thesis etd-05172016-112408


Thesis type
Tesi di laurea specialistica LC5
Author
WAIZMAN, MILLY
URN
etd-05172016-112408
Thesis title
Pharmacological properties, therapeutic efficacy and safety of use of ustekinumab in immune-mediated inflammatory diseases
Department
FARMACIA
Course of study
FARMACIA
Supervisors
relatore Prof. Blandizzi, Corrado
Keywords
  • ustekinumab
  • IMID
  • IL-23
  • IL-12
Graduation session start date
08/06/2016
Availability
Withheld
Release date
08/06/2086
Summary
Ustekinumab is a fully human monoclonal antibody, generated via molecular engineering from transgenic mice, genetically modified so they cannot produce murine antibodies, but only human antibodies. Ustekinumab binds in a selective manner to the p40 subunit which contributes to the structure of both IL-12 (p35/p40) and IL-23 (p19/p40), which play a key role in the pathogenesis of immune-mediated inflammatory diseases (IMIDs).
Note
La tesi in oggetto non è stata inserita correttamente nel data base dall’autore. L’autore stesso ed i relatori sono stati avvertiti di tale omissione
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