ETD

Archivio digitale delle tesi discusse presso l'Università di Pisa

Tesi etd-05022015-122100


Tipo di tesi
Tesi di laurea magistrale
Autore
TIRIBILLI, CHIARA
URN
etd-05022015-122100
Titolo
Study of electrochemical oxidation and reduction mechanism of diflunisal: a multi-analytical approach
Dipartimento
CHIMICA E CHIMICA INDUSTRIALE
Corso di studi
CHIMICA
Relatori
relatore Dott. Romana, Sokolova
relatore Prof.ssa Giannarelli, Stefania
controrelatore Dott.ssa Domenici, Valentina
Parole chiave
  • electro-oxidation and electro-reduction mechanism
  • diflunisal
  • cyclic voltammetry
  • chromatographic techniques
  • polarography
Data inizio appello
11/06/2015
Consultabilità
Non consultabile
Data di rilascio
11/06/2024
Riassunto
The purpose of this study was to investigate reduction and oxidation mechanisms at the electrode of diflunisal. The studies were performed in non aqueous solution. In summary, for the oxidation investigations, diflunisal mechanism was studied in acetonitrile on glassy carbon electrode using cyclic voltammetry. The number of electrons involved in the oxidation was studied with exhaustive electrolysis and spectroelectrochemical technique. The electrochemical properties of the drug were studied in presence of pyridine in order to investigate possible proton transfer associated to the electron transfer process. The products of electrolysis were determined using chromatographic techniques. A concise comparison with the electrochemical characteristics of the chlorinated analogue of diflunisal is reported. For the reduction part, the electrochemical reduction of diflunisal was studied in dimethyl sulfoxide on static mercury drop electrode using cyclic voltammetry and tast polarography. The number of electrons involved in the oxidation was studied with exhaustive electrolysis. The electrochemical properties of the drug were investigated in presence of proton donors and proton acceptors in order to examine plausible proton transfer preceding or following the electron transfer process. The products of electrolysis were determined using chromatographic techniques. The behavior of the drug on mercury electrode was compared in detail with the one of the chlorinated analogues.
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