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Tesi etd-04272015-112743


Thesis type
Tesi di laurea magistrale
Author
BARSACCHI, MARCO
URN
etd-04272015-112743
Title
Computational Investigation of the Switching Mechanism in Riboswitches
Struttura
INGEGNERIA DELL'INFORMAZIONE
Corso di studi
INGEGNERIA BIOMEDICA
Commissione
relatore Dott. Bechini, Alessio
Parole chiave
  • Secondary structure
  • Riboswitches
  • RNA
Data inizio appello
12/06/2015;
Consultabilità
completa
Riassunto analitico
Gene Regulation is one of the most important mechanisms at the basis of the widespread diffusion and versatility of organism. It provides the cell with an effective control means over structure and functions, with a direct connection to cellular differentiation, morphogenesis, and adaptability. <br>Until recently it has been common belief that only proteins were involved in gene regulation; later, regulatory functions have been discovered also for non-coding RNA; in particular, since the discovery of riboswitches such a simplistic perception has changed. <br>Riboswitches are regulatory elements, usually found in 5&#39; untranslated regions of bacterial mRNA, directly interacting with metabolites as a means of regulating expression of the coding region via a secondary structural switch. <br>Modelling riboswitch structural rearrangement would be a greater advance, not only for understanding key processes of this RNA functional elements, but will also speed up riboswitches engineering leading to a huge improvement in biotechnological application of these genetic switches.
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