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Tesi etd-04232009-111425


Thesis type
Tesi di dottorato di ricerca
Author
RESSEL, LORENZO
URN
etd-04232009-111425
Title
PTEN expression in canine and feline mammary tumours
Settore scientifico disciplinare
VET/03
Corso di studi
MEDICINA VETERINARIA
Supervisors
Relatore Prof. Poli, Alessandro
Parole chiave
  • overall survival
  • mammary tumours
  • dog
  • cat
  • PTEN
Data inizio appello
12/06/2009;
Consultabilità
Parziale
Data di rilascio
12/06/2049
Riassunto analitico
Phosphatase and tensin homolog (PTEN) belong to the group of gatekeepers tumour suppressor genes and is involved in multiple mechanisms leading to cellular defense against neoplastic transformation and progression. Twenty four dogs and 17 cats were submitted to a two-years follow-up and clinico-pathological features were recorded and compared with immunohistochemical PTEN expression. PTEN-negative status occurred in 33% of canine and 76% of feline mammary carcinomas. In canine mammary carcinomas there was a significant (P<0.05) correlation among PTEN loss of protein expression and simple carcinoma histotype, presence of lymphatic invasion, lymph-node metastases, distant organ metastases, tumour dedifferentiation, tumour recurrence, and shorter overall survival. In feline mammary tumours a significant correlation between PTEN protein expression and presence of lymphatic invasion was found. Loss of PTEN expression could be a useful prognostic marker in canine and perhaps feline mammary carcinomas.
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