Thesis etd-04012020-170501 |
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Thesis type
Tesi di dottorato di ricerca
Author
ORTENZI, VALERIO
URN
etd-04012020-170501
Thesis title
Laser-captured microdissection as a mean to look into Glioblastoma?s Tumor Micro-Environment heterogeneity
Academic discipline
MED/08
Course of study
SCIENZE CLINICHE E TRASLAZIONALI
Supervisors
tutor Prof. Naccarato, Antonio Giuseppe
Keywords
- glioblastoma
- microdissection
- microdissezione
- tumor microenvironment
Graduation session start date
08/04/2020
Availability
Withheld
Release date
08/04/2090
Summary
La microdissezione con cattura laser-assistita combinata con sequenziamento di nuova generazione applicato alle sequenze RNA di geni trascritti (LCM-seq) può costituire una metodica innovativa oltre che estremamente sensibile e specifica per studiare il microambiente tumorale e gettare le basi per una conoscenza più profonda dei glioblastomi, scoprire la loro origine ed elaborare nuove strategie terapeutiche per contrastarli.
Laser-capture assisted microdissection is a novel histological technique which can be paired with Next Generation Sequencing (NGS) in order to obtain genetic tissue from specific components of neoplasms, analyzing even expression profiles (RNA sequences) of single cells. Applying this combined technique to glioblastoma it would be possible to discover new ways to understand its complexity, plan new therapeutic strategies and find out hints about its misterious origin.
Laser-capture assisted microdissection is a novel histological technique which can be paired with Next Generation Sequencing (NGS) in order to obtain genetic tissue from specific components of neoplasms, analyzing even expression profiles (RNA sequences) of single cells. Applying this combined technique to glioblastoma it would be possible to discover new ways to understand its complexity, plan new therapeutic strategies and find out hints about its misterious origin.
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