Thesis etd-03262012-181717 |
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Thesis type
Tesi di specializzazione
Author
SCANDIFFIO, ROSSELLA
URN
etd-03262012-181717
Thesis title
3 Tesla MRI- Crohn disease activity score: correlation with Crohn Disease Activity Index (CDAI), endoscopic findings and biological markers.
Department
MEDICINA E CHIRURGIA
Course of study
RADIODIAGNOSTICA
Supervisors
relatore Prof. Bartolozzi, Carlo
correlatore Dott. Neri, Emanuele
correlatore Dott. Neri, Emanuele
Keywords
- 3T MRI
- Crohn
Graduation session start date
13/04/2012
Availability
Full
Summary
Aim
To work out a radiological score in the assessment of Crohn’s disease activity and severity.
Materials and methods.
From July 2011 to February 2012, 46 patients with suspected or established Crohn’s disease underwent small bowel MRI on a 3T scanner. According to radiological findings and disease behaviour phenotype (as proposed in the Montreal classification), patients were divided into 5 classes:
absence of disease
disease activity (presence of one of following findings: mucosal abnormalities, submucosal edema, mucosal enhancement)
presence of substenosis without obstruction
a. active disease
b. inactive disease
presence of stenosis with obstruction
a. active disease
b. inactive disease
extramural involvement (fistulas and/or abscess)
Data were correlated with endoscopical findings, CDAI, CRP and ESR.
Results
A significant correlation (r= 0.88, p< 0,001) was registered between endoscopical findings and MR score. A good correlation of MRI- CSI was observed with CDAI (r= 0,59, p<0,01); correlation was superimposable (r= 0,59, p<0,01) if subgroups were divided into active/ non active disease. A moderate correlation of MR- CSI was observed with ESR ( 0,49, p=0,001) and CRP (0,47, p=0,001). Correlation appears higher if subgroups were divided into active/ non active disease (0,66 and 0,59 respectively).
Conclusion
MR- CSI is a quick, manageable score, easy- to apply in daily practice; furthermore, MR can be used in the evaluation of CD as an alternative to ileocolonoscopy.
To work out a radiological score in the assessment of Crohn’s disease activity and severity.
Materials and methods.
From July 2011 to February 2012, 46 patients with suspected or established Crohn’s disease underwent small bowel MRI on a 3T scanner. According to radiological findings and disease behaviour phenotype (as proposed in the Montreal classification), patients were divided into 5 classes:
absence of disease
disease activity (presence of one of following findings: mucosal abnormalities, submucosal edema, mucosal enhancement)
presence of substenosis without obstruction
a. active disease
b. inactive disease
presence of stenosis with obstruction
a. active disease
b. inactive disease
extramural involvement (fistulas and/or abscess)
Data were correlated with endoscopical findings, CDAI, CRP and ESR.
Results
A significant correlation (r= 0.88, p< 0,001) was registered between endoscopical findings and MR score. A good correlation of MRI- CSI was observed with CDAI (r= 0,59, p<0,01); correlation was superimposable (r= 0,59, p<0,01) if subgroups were divided into active/ non active disease. A moderate correlation of MR- CSI was observed with ESR ( 0,49, p=0,001) and CRP (0,47, p=0,001). Correlation appears higher if subgroups were divided into active/ non active disease (0,66 and 0,59 respectively).
Conclusion
MR- CSI is a quick, manageable score, easy- to apply in daily practice; furthermore, MR can be used in the evaluation of CD as an alternative to ileocolonoscopy.
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