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Tesi etd-03252020-165135


Thesis type
Tesi di laurea magistrale
Author
CHIAVERINI, LORENZO
URN
etd-03252020-165135
Title
New organometallic diiron complexes with potential anticancer activity
Struttura
CHIMICA E CHIMICA INDUSTRIALE
Corso di studi
CHIMICA
Supervisors
relatore Prof. Marchetti, Fabio
Parole chiave
  • organometallic synthesis
  • anticancer metal compounds
  • diiron complexes
Data inizio appello
15/04/2020;
Consultabilità
Secretata d'ufficio
Riassunto analitico
This work of thesis consisted in the synthesis of new diiron bridging thiocarbyne complexes with potential anticancer activity. Starting from complex [Fe2Cp2(CO)3CSMe][CF3SO3] a variety of derivatives were synthesized substituting one or both terminal CO ligands. Mixed complexes containing one phosphine and one isocyanide were prepared with the intent of creating an appropriate balance between hydrophilicity and lipophilicity, that is an important requisite for a potential drug. Behaviour of all these complexes in aqueous solutions was evaluated for the first time.
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