ETD system

Electronic theses and dissertations repository

 

Tesi etd-03052015-131448


Thesis type
Tesi di dottorato di ricerca
Author
LUPI, GIANCARLO
URN
etd-03052015-131448
Title
Development of polymeric vascular connection device for small diameter vascular by-pass
Settore scientifico disciplinare
CHIM/04
Corso di studi
SCIENZE BIOLOGICHE E MOLECOLARI
Commissione
tutor Prof. Ferrari, Mauro
commissario Prof.ssa Bigi, Adriana
commissario Prof. Ciardelli, Gianluca
commissario Prof. Ruggeri, Giacomo
tutor Prof.ssa Chiellini, Federica
Parole chiave
  • microsurgery
  • stented anastomoses
  • absorbable sten
Data inizio appello
17/03/2015;
Consultabilità
completa
Riassunto analitico
The work performed in the accomplishment of the PhD Thesis focused on the<br>development of a new polymeric vascular re absorbable connection device has<br>been implemented in 4 chapters whose content is summarized by following:<br>1. Review on Sutureless devices: this chapter includes a literature review of all<br>devices for vascular anastomoses designed and constructed over the years; the<br>research provides the basis from which we started. In particular, we performed a<br>careful analysis of the advantages and benefits described for each class of device,<br>divided according to their prevailing mechanism of action. Some basic<br>biomechanics principles of intravascular tubes and stents are listed.<br>2. Preparation and characterization of biodegradble polymeric stents for<br>small diameter vascular by pass: this chapter describes the preparation and<br>chemical and physical characterization of the wet-spun biodegradable<br>polymeric stents. The processing parameters for the production of small<br>calibre tubular polymeric devices were investigated.<br>3. In vitro Biological Characterizations of Polymeric Vascular Connection<br>Device for Small Diameter Vascular By-pass: This chapter is focused on the<br>behaviour of HUVEC and Fibroblast cells when seeded on PCL and PHBHHx<br>stents. Several in-vitro assays are taken into consideration to evaluate cell<br>attachment and proliferation.<br>4. Preliminary ex-vivo and in-vivo study of sutureless microvascular<br>anastomosis with endoluminal re-absorbable stent coupled with the laser<br>welding technique: preliminary “ex-vivo” and “in-vivo” evaluation of the<br>stents prototypes are presented to assess their suitability to withstand the<br>surgical manoeuvres needed to insert them into carotid artery.
File