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Tesi etd-02282020-144737


Tipo di tesi
Tesi di laurea magistrale
Autore
DRAGONE, NICOLA
URN
etd-02282020-144737
Titolo
Sintesi di analoghi dello Pterostilbene e valutazione preliminare delle loro attività biologiche
Dipartimento
CHIMICA E CHIMICA INDUSTRIALE
Corso di studi
CHIMICA
Relatori
relatore Prof. Angelici, Gaetano
relatore Dott. Lessi, Marco
controrelatore Prof.ssa Chiellini, Federica
Parole chiave
  • amino acids
  • cross coupling
  • organic chemistry
  • Pterostilbene
Data inizio appello
15/04/2020
Consultabilità
Non consultabile
Data di rilascio
15/04/2090
Riassunto
Synthesis of functionalizable analogues of Resveratrol and Pterostilbene and their conjugation to peptide sequences, like new lead molecules with antimicrobial, antioxidant or antitumor activity. By using of simple and inexpensive methodologies for C-C bond formation, functionalized analogues of Resveratrol and Pterostilbene were prepared and amino acid sequences were subsequently linked on them. In detail, the analogues indicated above were functionalized with amino, hydroxyl and carboxylic groups, functional groups which will allow the peptide sequence to be subsequently inserted through the formation of an ester or peptidic bond. The insertion of the peptide sequence will have two possible functions: conveying and releasing the organic (bioactive) scaffold within the organism or increasing the biological properties of the bioactive molecule thanks to a synergy of molecule action / peptide. To this end, the inserted peptide sequences must be chosen not only on the basis of the role they must have (carrier or biological action) but also on the biological target on which they must act.
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