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ETD

Digital archive of theses discussed at the University of Pisa

 

Thesis etd-02262013-191122


Thesis type
Tesi di dottorato di ricerca
Author
CASTELLI, FRANCESCA
URN
etd-02262013-191122
Thesis title
The endocannabinoid system: 1. Design, synthesis and biological evaluation of heterocyclic derivatives as potential MAGL inhibitors. 2. Study of the ischemic damage effects in cannabinoid receptors knockout mice.
Academic discipline
CHIM/08
Course of study
FISIOPATOLOGIA CLINICA E SCIENZE DEL FARMACO
Supervisors
tutor Prof.ssa Manera, Clementina
Keywords
  • cannabinoid
  • ischemic disease
  • MAGL inhibitor
Graduation session start date
27/03/2013
Availability
Full
Summary
My PhD thesis is about the study of different aspect of endocannabinoid system. In particular during my reserach project I focused my attention on two different topics:
1. Design, synthesis and biological evaluation of heterocyclic derivatives as potential MAGL inhibitors, which could be use for the treatment of different kind of disease, such as neurological disease, cancer, glaucoma, sclerosis etc...
2. Study of the ischemic damage effects in CB2 receptors knockout and CB1-CB2 receptors double knockout mice of both sexes.
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