ETD

Digital archive of theses discussed at the University of Pisa

Thesis etd-02262013-191122

Thesis type

Tesi di dottorato di ricerca

URN

etd-02262013-191122

Thesis title

The endocannabinoid system: 1. Design, synthesis and biological evaluation of heterocyclic derivatives as potential MAGL inhibitors. 2. Study of the ischemic damage effects in cannabinoid receptors knockout mice.

Academic discipline

CHIM/08 - CHIMICA FARMACEUTICA

Course of study

FISIOPATOLOGIA CLINICA E SCIENZE DEL FARMACO

Keywords

cannabinoid
ischemic disease
MAGL inhibitor

Graduation session start date

27/03/2013

Availability

Full

Abstract (Inglese)

Abstract (Italiano)

My PhD thesis is about the study of different aspect of endocannabinoid system. In particular during my reserach project I focused my attention on two different topics:
1. Design, synthesis and biological evaluation of heterocyclic derivatives as potential MAGL inhibitors, which could be use for the treatment of different kind of disease, such as neurological disease, cancer, glaucoma, sclerosis etc...
2. Study of the ischemic damage effects in CB2 receptors knockout and CB1-CB2 receptors double knockout mice of both sexes.

File

Nome file	Dimensione
PhD_thes...telli.pdf	3.60 Mb
Contatta l’autore