ETD system

Electronic theses and dissertations repository

 

Tesi etd-02262013-191122


Thesis type
Tesi di dottorato di ricerca
Author
CASTELLI, FRANCESCA
URN
etd-02262013-191122
Title
The endocannabinoid system: 1. Design, synthesis and biological evaluation of heterocyclic derivatives as potential MAGL inhibitors. 2. Study of the ischemic damage effects in cannabinoid receptors knockout mice.
Settore scientifico disciplinare
CHIM/08
Corso di studi
FISIOPATOLOGIA CLINICA E SCIENZE DEL FARMACO
Commissione
tutor Prof.ssa Manera, Clementina
Parole chiave
  • MAGL inhibitor
  • ischemic disease
  • cannabinoid
Data inizio appello
27/03/2013;
Consultabilità
completa
Riassunto analitico
My PhD thesis is about the study of different aspect of endocannabinoid system. In particular during my reserach project I focused my attention on two different topics:<br>1. Design, synthesis and biological evaluation of heterocyclic derivatives as potential MAGL inhibitors, which could be use for the treatment of different kind of disease, such as neurological disease, cancer, glaucoma, sclerosis etc...<br>2. Study of the ischemic damage effects in CB2 receptors knockout and CB1-CB2 receptors double knockout mice of both sexes.
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