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Digital archive of theses discussed at the University of Pisa

 

Thesis etd-02232014-151212


Thesis type
Tesi di dottorato di ricerca
Author
MIGONE, CHIARA
URN
etd-02232014-151212
Thesis title
Three-dimensional polymeric systems for cancer cells studies
Academic discipline
BIO/11
Course of study
SCIENZE BIOLOGICHE E MOLECOLARI
Supervisors
tutor Chiellini, Federica
Keywords
  • pancreatic cancer
  • three-dimensional scaffold
  • tissue engineering
Graduation session start date
14/03/2014
Availability
Full
Summary
The present research activity is aimed at the development of 3D culture of pancreatic
cancer cells in microstructured polymer matrices in order to gain insights in the
regulation of pancreatic cancer cell proliferation as well as in the view of developing an
in vitro model for the evaluation of novel anticancer drugs.
The research activity will be performed under a multidisciplinary approach and all the
described objectives will be part of three chapters that constitute the body of this work:
1) Three-dimensional polyelectrolyte complexes hydrogels based on chitosan and
poly(γ-glutamic acid): preparation and physical-chemical characterization
2) Biocompatibility assessment of polyelectrolyte complexes hydrogels
3)Modeling of pancreatic ductal adenocarcinoma in vitro with three-dimensional
microstructured polyelectrolyte complexes hydrogels
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