ETD system

Electronic theses and dissertations repository

 

Tesi etd-02222008-103352


Thesis type
Tesi di dottorato di ricerca
Author
GIUSTI, SABINA
URN
etd-02222008-103352
Title
Prostate cancer: pre-treatemnt evaluation with Magnetic Resonance Imaging and three-dimensional 1H-Magnetic Resonance Spectroscopy
Settore scientifico disciplinare
MED/36
Corso di studi
TECNOLOGIE PER LA SALUTE: VALUTAZIONE E GESTIONE DELLE INNOVAZIONI NEL SETTORE BIOMEDICALE
Commissione
Relatore Prof. Pietrabissa, Andrea
Parole chiave
  • MRS
  • MRI
  • cancer
  • Prostate
Data inizio appello
10/03/2008;
Consultabilità
completa
Riassunto analitico
Prostate cancer is the most frequent malignancy of the male genitourinary tract, with an incidence in Europe of approximately 30 per 100.000 [48,49]. MRI of the prostate with a combined pelvic and endorectal coil has become an accepted method for staging prostate cancer. The advantages of this technique get results especially in local staging sensitivity, with a better judgement of surrounding structures [50,51]. Three-dimensional 1H-spectroscopy (3D MRS) of the prostate with evaluation of the metabolites choline, creatine, and citrate is a promising method for detecting prostate carcinomas which in particular show a higher choline and a reduced citrate level in comparison with healthy prostatic tissue [52,53]. <br>The first objective of our study was to assess sensitivity, specificity and accuracy of 3-D MRI and 3D MRS in patients with high prostate-specific antigen (PSA) levels and biopsy proven prostate carcinoma, candidate to radical prostatectomy. <br>The second purpose was to find a cut-off value of (Cho+Cr)/Cit ratio to discriminate between normal peripheral zone tissue and cancer. <br>Besides we find a correlation between (Cho+Cr)/Cit ratio and histologic Gleason score.<br>
File