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Tesi etd-02202020-181148


Tipo di tesi
Tesi di dottorato di ricerca
Autore
GUARRA, FEDERICA
URN
etd-02202020-181148
Titolo
Gold and silver N-heterocyclic carbenes as prospective anticancer agents
Settore scientifico disciplinare
CHIM/03
Corso di studi
SCIENZE CHIMICHE E DEI MATERIALI
Relatori
tutor Prof.ssa Gabbiani, Chiara
supervisore Dott.ssa Biver, Tarita
Parole chiave
  • binding mechanism
  • cytotoxicity
  • gold(III)
  • metal complexes
  • radiolabelling
Data inizio appello
28/02/2020
Consultabilità
Completa
Riassunto
Silver(I) and gold(I) N-heterocyclic carbenes have been designed, and investigated for their interaction with proteins and nucleic acids. Experiments on cancer cell cultures allowed investigation of the localization, the uptake and the cytotoxicity of the compounds.
An unprecedented radiolabelling strategy has been employed for the evaluation of the in vivo biodistribution and stability of a gold(III) N-heterocyclic carbene. The antiproliferative activity has been investigated at a cellular level. In this regard, the comparison with the gold(I) precursor and reference compounds gave complementary insights.
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