ETD system

Electronic theses and dissertations repository

 

Tesi etd-01232018-130126


Thesis type
Tesi di laurea magistrale
Author
RICCIO, FIORELLA
URN
etd-01232018-130126
Title
Design of new testing strategies for the real time viscoelastic characterization of cell laden hydrogels in the MCTR bioreactor
Struttura
INGEGNERIA DELL'INFORMAZIONE
Corso di studi
INGEGNERIA BIOMEDICA
Supervisors
relatore Prof.ssa Ahluwalia, Arti Devi
correlatore Dott.ssa Cacopardo, Ludovica
controrelatore Prof.ssa Di Puccio, Francesca
Parole chiave
  • validation of new testing method
  • sigmadot
Data inizio appello
16/02/2018;
Consultabilità
Parziale
Data di rilascio
16/02/2021
Riassunto analitico
The present thesis is based on the validation of a new stimulation method, the sigmadot, used in a new bioreactor, the Mechanoculture TR, to characterize the biomaterials viscoelastic properties in real - time.
The first phase of the thesis was focused on the design and validation of the new testing method and on the study of the bioreactor, thanks to preliminary tests and a FEM model. Then, the work was focused on the production and characterization of liver ECM, as a substrate for the realization of pathophysiological 3D models, thanks to an enzymatic stiffening method. This method allows to obtain a cell-laden 3D gels with tunable stiffness, in order to mimic the progression of liver fibrosis, thus resulting in an ideal application for the new testing method developed in this thesis
File