ETD system

Electronic theses and dissertations repository

 

Tesi etd-01152013-173253


Thesis type
Tesi di dottorato di ricerca
Author
POPOVIC, DINA
URN
etd-01152013-173253
Title
PREDOMINANT POLARITY AND THE POLARITY INDEX OF DRUGS USED IN MAINTENANCE TREATMENT OF BIPOLAR DISORDER
Settore scientifico disciplinare
MED/25
Corso di studi
NEUROSCIENZE E SCIENZE ENDOCRINOMETABOLICHE
Commissione
tutor Dott. Perugi, Giulio
correlatore Prof. Vieta, Eduard
Parole chiave
  • polarity index
  • mood stabilizers
  • maintenance treatment
  • bipolar disorder
  • antipsychotics
Data inizio appello
23/01/2013;
Consultabilità
completa
Riassunto analitico
Objective: Predominant polarity (PP) is an important variable in maintenance treatment of Bipolar Disorder (BD). This study aimed at determining the role of Polarity Index (PI), a metric indicating antimanic versus antidepressive prophylactic potential of drugs, in clinical decision-making. <br>Method: 257/604 (43%) of patients with BD-I or II fulfilled criteria for manic (MPP) or depressive PP (DPP).<br>The PI, representing Number Needed to Treat (NNT) for prevention of depression and NNT for mania prevention ratio, was calculated for patients’ current treatment.<br>MPP and DPP groups were compared regarding sociodemographic, clinical and therapeutic characteristics.<br>Results: 143 patients (55.6%) fulfilled criteria for DPP and 114 (44.4%) for MPP. <br>Total PI, Antipsychotics’ PI and Mood Stabilizers PI were higher, indicating a stronger antimanic action, in MPP. MPP presented higher prevalence of BD-I, male gender, younger age, age at onset and at first hospitalization, more hospitalizations, primary substance misuse and psychotic symptoms. DP correlated with BD-II, depressive onset, primary life events, melancholia and suicide attempts.<br>Conclusion: The results confirm the usefulness of the PI. In this large sample, clinical differences among these groups justify differential treatment approach. The PI appears to be a useful operationalization of what clinicians do for maintenance therapy in BD.<br>
File