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Tesi etd-08292014-115425


Tipo di tesi
Tesi di laurea magistrale
Autore
AGONIGI, GABRIELE
URN
etd-08292014-115425
Titolo
Synthesis of Ruthenium and Osmium Complexes with potential anticancer activity
Struttura
CHIMICA E CHIMICA INDUSTRIALE
Corso di studi
CHIMICA INDUSTRIALE
Commissione
relatore Dott. Marchetti, Fabio
Parole chiave
  • NAMI
  • osmium arene
  • ruthenium arene
  • anticancer
Data inizio appello
18/09/2014;
Disponibilità
completa
Riassunto analitico
Aim of the work

This work is focused on the synthesis of new Ru and Os complexes with potential anticancer activity. The design of the new compounds has been based on metal frames bearing structures with ascertained anticancer activity (ruthenium , and osmium arenes, simil-NAMI , ); such metal frames have been associated with newly prepared suitable ligands.
The new ligands have been designed and obtained by coupling a skeleton containing one heteroatom (N or P), able to coordinate Ru and Os centers, with a fragment derived from ethacrynic acid . In particular, pyridines and PPh3 have been used to the purpose, since both types of compounds have been reported to act as enhancers of antiproliferative activity.
The synthesis of the Os complexes has been carried out at the University of Zaragoza (E), under the supervision of Prof. M. A. Esteruelas.
The anticancer activity of the prepared Ru and Os complexes will be tested at the École Polytechnique Fédérale de Lausanne (EPFL).
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