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Tesi etd-05072019-104238


Thesis type
Tesi di laurea magistrale LM5
Author
FRENN, FABIENNE
URN
etd-05072019-104238
Title
Links between the persistent organic pollutants and the components of the metabolic syndrome in a Lebanese population
Struttura
FARMACIA
Corso di studi
FARMACIA
Commissione
relatore Prof. Calderone, Vincenzo
Parole chiave
  • Persistent organic pollutants
  • human biomonitoring
  • lebanese population
  • polychrlorinated biphenyls
  • metabolic syndrome
Data inizio appello
29/05/2019;
Consultabilità
secretata d'ufficio
Riassunto analitico
Polychlorinated biphenyls (PCBs) are persistent organic pollutants that are still routinely detected 30 years after their restriction in many countries. PCBs have been associated with several non-communicable diseases. They are best measured via “Human Biomonitoring” (HBM). The concentrations of six indicator PCBs (PCBs 28, 52, 101, 138, 153 and 180) were measured in the serum samples of 316 Lebanese population, using gas chromatography coupled to an iron trap mass spectrometer detector. PCBs were detected in 56.3 to 59.2% of the serum samples. The sum of PCB (∑PCB) levels ranged from < LOD to 338.84 ng/g lipids, with a geometric mean level of 10.34 ± 0.98 ng/g lipids. The major contributor to the ∑PCBs was PCB 180. In the present study, the levels were in general lower than the values observed in several Western and European countries. No association was found between age and concentration of any of the PCBs. In terms of risk for health, the highest levels were lower than critical limits as such as HBM I and II values. We observed an inverted U-shaped association between levels of serum PCBs and the risk of overweight/obesity. Regarding potential food contributors, we found no relation between PCB levels and fish consumption and a moderate relation with dairy products consumption (moderate consumers of dairy products had higher PCB levels compared to lower consumers (16.92±0.1/6.92±0.12; p=0.025). The present study is the first to provide information regarding PCB levels in a Lebanese population. Larger studies are required in order to estimate the PCB exposure parameters of the Lebanese population
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