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Tesi etd-11222019-090238


Thesis type
Tesi di laurea magistrale LM6
Author
SANTONI, LORENZA
URN
etd-11222019-090238
Title
Myotonic Dystrophy Type 1 and the Serious Game X-Torp: Results of a Feasibility Study
Struttura
RICERCA TRASLAZIONALE E DELLE NUOVE TECNOLOGIE IN MEDICINA E CHIRURGIA
Corso di studi
MEDICINA E CHIRURGIA
Supervisors
relatore Prof. Siciliano, Gabriele
correlatore Prof.ssa Sacconi, Sabrina
Parole chiave
  • Steinert's Disease
  • Myotonic Dystrophy Type 1
  • Serious Game
  • X-Torp
  • MIRS
  • diagnostic assessment
  • FSS
  • fatigue
  • 6 minute walking test
  • FAB
  • SCEB
  • PANAS
  • Digit Span
  • TMT
Data inizio appello
10/12/2019;
Consultabilità
Secretata d'ufficio
Data di rilascio
10/12/2089
Riassunto analitico
This thesis presents the results of a feasibility study concerning the use of the Serious Game X-Torp in patients with myotonic dystrophy type 1.
Serious Games are games with a primary purpose other than pure entertainment, in this case X-Torp has been developed in the context of the project Az@GAME to be used in Alzheimer and associated pathologies for the assessment and rehabilitation of patients with Alzheimer's Disease and other types of cognitive impairment. Later it has been proposed for other neurological conditions, again for assessment and rehabilitation.
Myotonic dystrophy type 1 (DM1) is a multisystemic, autosomal dominant disease, involving muscle, with weakness and myotonic phenomenon, and several other organs, for example, central nervous system, ocular system, cardiac conduction system, and respiratory system.
The primary objective of this thesis is to assess the feasibility of the application of X-Torp in patients with DM1 in a larger study, to assess its use in a regular rehabilitation program. The secondary objectives include the evaluation of the risk associated with the use of X-Torp, the ability of X-Torp to stratify patients according to their level of physical and cognitive impairment, the assessment of the clinical tolerance to the use of X-Torp, the evaluation of the correlation between daily fatigue and fatigue after a game session, and the evaluation of the subjective perception of the game experience and the willingness of the patients to use X-Torp as a rehabilitative tool.
The results are encouraging towards both the primary and secondary objectives. The majority of the patients was able to perform a game session longer than 15 minutes and no secondary effects were reported. The patients have generally shown favourable opinions about this experience, also with regards to its regular use for rehabilitation purposes. Some correlations between clinical and neuropsychological scores and game results have been found and support the application of X-Torp to assess and follow the progression of the disease.
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