ETD system

Electronic theses and dissertations repository

 

Tesi etd-07272016-004812


Thesis type
Tesi di laurea magistrale
Author
PETRUCCO, LUIGI
URN
etd-07272016-004812
Title
Focal interictal activity in the mouse visual cortex interferes with slow-wave oscillations and visual processing in the contralateral hemisphere
Struttura
BIOLOGIA
Corso di studi
BIOLOGIA APPLICATA ALLA BIOMEDICINA
Supervisors
relatore Dott. Ratto, Gian Michele
correlatore Prof. Pellegrino, Mario
relatore Prof. Cammalleri, Maurizio
Parole chiave
  • epilepsy
  • mouse
  • visual
  • cortex
  • electrophysiology
  • interictal spike
Data inizio appello
26/09/2016;
Consultabilità
Completa
Riassunto analitico
Epileptiform activity is associated with impairment of brain function even in absence of seizures, as demonstrated by failures in various testing paradigm in presence of hypersynchronous interictal spikes (ISs). Clinical evidence suggests that cognitive deficits might be directly caused by the anomalous activity rather than by its underlying etiology. Here, I seek to understand whether focal ISs interfere with neuronal processing in connected areas not directly participating in the hypersynchronous activity. I caused focal ISs in the visual cortex of anesthetized mice and we determined that, even if IS did not invade the opposite hemisphere, the EEG was subtly disrupted with a modulation of firing probability imposed by the contralateral IS activity. Finally, we found that visual perception was altered depending on the temporal relationship between ISs and stimulus presentation. We conclude that focal ISs interact with normal cortical dynamics far from the epileptic focus, disrupting endogenous oscillatory rhythms and affecting information processing.
File