ETD system

Electronic theses and dissertations repository

 

Tesi etd-07052016-095435


Thesis type
Tesi di specializzazione (5 anni)
Author
CASERTA, ANNA
URN
etd-07052016-095435
Title
Irritable bowel syndrome in psychiatric perspective : clinical and therapeutic implications.
Struttura
MEDICINA CLINICA E SPERIMENTALE
Corso di studi
PSICHIATRIA
Commissione
relatore Prof.ssa Dell'Osso, Liliana
Parole chiave
  • Irritable bowel syndrome
  • Treatment
  • Comorbidities
  • Psychiatric disorders
Data inizio appello
22/07/2016;
Consultabilità
completa
Riassunto analitico
Irritable Bowel Syndrome (IBS) is the most common functional gastrointestinal (GI)<br>disorder observed in patients who visit general practitioners for GI­related complaints. A<br>high prevalence of psychiatric comorbidities, particularly anxiety and depressive<br>disorders, has been reported in patients with IBS, suggesting that this association should<br>always be considered in this setting.<br>In order to better define the relationship between IBS and psychiatric disorders, one<br>hundred and fifty subjects with diagnosis of IBS and relative sub­classification<br>(constipated, diarrhea and alternating bowel) were assessed for gastrointestinal and<br>mental functioning at the Gastroenterological Department of University of Pisa.<br>Over half of the subjects in the sample (56%) showed “psychopathological features”<br>(term that covers both Axis I diagnosis both previous or current drug / psychological<br>treatment). In this group GI symptoms severity was higher and quality of life more<br>unsatisfactory than in the group without any psychiatric implications (44%).<br>Second objective of the study was to examine the efficacy of SSRI (paroxetine) in IBS<br>patients. With the limit due to small sample size of IBS patients suitable for treatment<br>paroxetine showed a significant improvement not only at psychiatric but also at GI<br>evaluations. Moreover, efficacy on abdominal symptoms was independent by the<br>presence of psychopathological features or by quality of life and satisfaction.<br>Consequently this study emphasizes the importance of the assessment of all IBS subjects<br>for clear or subclinical psychiatric comorbidities that are suggestive to correlate with the<br>severity of GI symptoms and functional impairment.<br>
File