ETD

Digital archive of theses discussed at the University of Pisa

 

Thesis etd-06282021-105904


Thesis type
Tesi di laurea magistrale
Author
URSO, ILARIA
URN
etd-06282021-105904
Thesis title
Design and development of a miniaturized device for dermoscopic and spectroscopic analysis of skin lesions
Department
INGEGNERIA DELL'INFORMAZIONE
Course of study
INGEGNERIA BIOMEDICA
Supervisors
relatore Prof. Ciuti, Gastone
Keywords
  • Melanoma detection
  • dermoscopy
  • spectroscopy
  • multimodal device
  • G-Fresnel lens
Graduation session start date
16/07/2021
Availability
Withheld
Release date
16/07/2091
Summary
According to the World Health Organization skin cancer, melanoma and non-melanoma, accounted for 8% of all cancer cases in 2020. Melanoma skin cancer is the least common skin cancer, only 21% of the total cases belong to this type but it shows the highest mortality rate (17% for melanoma and 5% for non-melanoma). There is a direct correlation between the thickness of the skin cancer and the mortality, early detection thus plays a crucial role in reducing patient mortality. The purpose of this thesis is to design and develop a miniaturized and low cost multimodal skin lesion inspection device for pre-screening and screening of melanoma. The instrument includes a dermoscopic module, that is the gold standard, and a spectroscopic module. The presence of the two modules makes the prototype an innovative device as it combines the ability to perform qualitative and quantitative lesion analysis in a single device. The spectroscopy module indeed improves performance by providing additional information and making the analysis independent of the physician's experience. The device includes an illumination system necessary for the operation of both modules. Taking into account device requirements and limitations, a circular ring array of 12 LEDs (6 VIS and 6 NIR) was chosen as the illuminator. The illuminator bandwidth was decided on the basis of the literature review. The major limitations to achieving an economic and low cost device were due to the spectroscopy module. So to reduce the overall cost and dimensions of the system a compact and economical spectroscope to be obtained by the use of a G-Fresnel lens. This PDMS optical element, that merges the functions of light focusing and light diffractions, was produced in house using the economical surface molding method.
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