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Tesi etd-06222016-153506


Thesis type
Tesi di laurea magistrale
Author
D'ANGIOLO, MELANIA JENNIFER
URN
etd-06222016-153506
Title
Genome analysis of natural and designed yeast hybrids
Struttura
BIOLOGIA
Corso di studi
BIOLOGIA MOLECOLARE E CELLULARE
Commissione
relatore Marangoni, Roberto
relatore Liti, Gianni
Parole chiave
  • yeast
  • introgression
  • Sacharomyces cerevisiae
  • lievito
  • hybrid
Data inizio appello
18/07/2016;
Consultabilità
parziale
Data di rilascio
18/07/2019
Riassunto analitico
Hybridization is an important source of genome evolution and this process has been documented in many species. The budding yeast Saccharomyces pastorianus, used worldwide for lager beer fermentation, originated from a spontaneous hybridization event between S. cerevisiae and S. eubayanus. Although yeast interspecies hybrids are considered a genetic dead end, population genomic analysis have identified many examples of interspecies introgressions in both natural and industrial Saccharomyces strains.Current models for genomic introgressions consist of an initial hybridization event followed by a rare viable hybrid spores and subsequent backcrossing. However, the very low viability (&lt;1%) and low chromosome recombination in the gametes, make it difficult to reconcile with the chimeric recombine chromosomes observed in extant species. We recently showed that highly recombined hybrid genomes can be derived without the full meiotic process (Laureau R et al, PLoS Genet. 2016 Feb 1;12(2):e1005781). Here, we tested whether alternative mitotic recombination could play a role in the evolution of the hybrid genomes.<br>
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