• glicolisi
• inibitori LDH-A
• ipossia
• LDH
• metabolismo del glucosio

The hypoxia occurs when there is fast-growing solid tumor formation characterized by angiogenesis. The resistance of hypoxic cancer cells to radiation and anticancer drugs necessitates the search for new therapeutic approaches to affect the metabolism of these cells.
The attenuation of glycolysis in cancer cells, particularly through the inhibition of LDH-A may provide a new therapeutic strategy to counteract the development of cancer.
The objective of the first part of thesis was to synthesize new compounds that can inhibit the A isoform of lactate dehydrogenase. The second part focused on the computational study of some synthesized compounds; in particular I have performed docking calculations, minimization and molecular dynamics. I have also dealt with the development of a pharmacophore model, then used as a filter for the process of virtual screening to identify new potentially active molecules.