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Tesi di specializzazione (5 anni)
Long term left atrium remodelling after successful reduction of the left ventricular outflow tract obstruction with surgical myectomy in patients with hypertrophic cardiomyopathy.
PATOLOGIA CHIRURGICA, MEDICA, MOLECOLARE E DELL'AREA CRITICA
Course of study
MALATTIE DELL'APPARATO CARDIOVASCOLARE
relatore Marzilli, Mario
- left atrium remodelling
- Hypertrophic cardiomyopathy
Graduation session start date
The left atrium (LA) enlargement in patients with hypertrophic cardiomyopathy (HCM) is a marker of disease progression and adverse prognosis. LA dilatation in patients with HCM is multifactorial and related to left ventricular outflow tract obstruction (LVOT), Mitral regurgitation (MR), left ventricular diastolic dysfunction, LV raised endiastolic pressures and genetic individual factors. Surgical myectomy is the gold standard procedure for the reduction of the LVOT obstruction, reducing also SAM-related mitral regurgitation (MR). Long term effects on the LA size and remodeling following successful surgical myectomy are unknown.