Thesis etd-05122013-155725 |
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Thesis type
Tesi di laurea magistrale
URN
etd-05122013-155725
Thesis title
Analysis of genomic and metagenomic libraries of marine epiphytic bacteria to isolate and characterize the antinematode activity when screened against Caenorhabditis elegans.
Department
BIOLOGIA
Course of study
BIOLOGIA MARINA
Supervisors
.
relatore Prof. Verni, Franco
Keywords
- antinematode
- Caenorhabditis elegans
- fosmid libraries
- functional genomic screen
- functional metagenomic screen
- marine bacteria
- marine bioactives
Graduation session start date
13/06/2013
Availability
Withheld
Release date
13/06/2053
Abstract (Inglese)
Abstract (Italiano)
The main purpose of this thesis was to screen genomic and metagenomic libraries of epiphytic bacterial communities previously isolated from the surface of marine seaweed Ulva australis and Delisea pulchra. Through functional screening against the nematode Caenorhabditis elegans, the bacterial clones at the subject of this thesis have been characterized for their antinematodal activity. Here I showed that marine microorganisms are a source of bioactivity against the nematode C. elegans and those bacterial secondary metabolites might lead in the long terms to pharmaceuticals and better nematode management strategies.
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